Quiz: Another Exam

1 The following is the main passive process of passage of drugs through cell membranes:

A A. simple diffusion B B. endocytosis C C. facilitated diffusion D D. filtration

2-Acidic drug in acidic media will become:

A A. ionized B B. unionized C C. lipid soluble D D. water soluble

3- To an unconscious patient, drugs should not be given:-

A a- orally B b- intravenous C c- by inhalation D d- d-intramuscular

4- Severe irritant drugs can be given:-

A a- Intramuscular B b- Subcutaneous C c- Intravenous

5-The best drug bioavailability occurs with taking drugs :

A a- Intramuscular B b- Rectal C c- Subcutaneous D d- Oral E e- Intravenous

6- The following drug is not effective against inflammatory diseases :

A a- acetylsalicylic acid B b- sodium salicylates C c- diclofenac D d- paracetamol

7-Children with viral infections should avoid:

A a- diclofenac B b- acetylsalicylic acid C c- paracetamol D d- indomethacin

8-Corticosteroids are used in autoimmune diseases due to its:

A a- Anti-inflammatory B b- antiallergic C c- Immunosuppressive effect D d- hypoglycemic effect

9-Methotrexate is used for treatment of:

A a- cancer B b- viral diseases C c- bacterial infections D d- fungal infection E e- a+b

10- Programmed cell death is called:

A a. Degeneration. B b. Necrosis C c. Aplasia. D d. Apoptosis.

11-Oedema is localized in all EXCEPT:

A A) Acute inflammation. B B) Chronic lymphatic obstruction. C C) Malnutrition. D D) Allergy

12- Histaminis released from:

A A) Platelets. B B) Neutrophiles. C C) All leukocytes. D D) Mast cells and basophiles.

13. Which of the followings is the source of epithelioid cells in granuloma?

A A) Macrophages. B B) Lymphocytes. C C) Neutrophils. D D) Plasma cells.

14- A reddish connective tissue that forms on the surface of wounds when they are healing is called:

A A) Fibrous tissue. B B) Granulation tissue. C C) Regenerative tissue. D D) Necrotic tissue.

15- Change of one type of tissue to another type is called:

A A) Hyperplasia. B B) Hypertrophy. C C) Metaplasia. D D) Dysplasia.

17- A malignant tumor is usually

A A) Capsulated. B B) Invasive. C C) Localized. D D) Well circumscribed

1- Degenerative disease classified to except

A A. cardiovascular disease B B. nervous system C C. neoplastic disease D D. renal disease

2- Types of inflammatory disease

A a- acute inflammation B b- Both A and B C c- chronic inflammation D d- none of the above

3- risk factor of neoplastic disease all the following

A e- age B f- infection C g- Ionizing radiation D h- all of the above

4-the most important investigation of neoplastic disease is

A a. biopsy B b. ultrasound C c. CBC D d. non of the above

5-type of chromosomal disorder in genetic disease?

A A. whole chromosome disorder B B. Both A and B C C. segment chromosome disorder D D. non

6- Degenerative diseases have relation to except

A A) aging B B) exercise C C) C-genetics D D) d-bacterial infection

1. Hypoproteinemia affects drugs in blood as follows:

A A. The free part is increased B B. The free part is decreased C C. The bound part is increased D D. None of the above

2. The following drugs are enzyme inducers EXCEPT:

A A. Rifampicin B B. Phenobarbitone C C. Testosterone D D. Estrogen

3. Excretion of drugs occurs mainly by:

A A. Kidney B B. Liver C C. Bile D D. Stool

4. Drug biotransformation occurs mainly in:

A A. Liver B B. Kidney C C. GIT mucosa D D. Lungs

Methotrexate is used for treatment of:

A A. Cancer B B. Bacterial infections C C. Viral diseases D D. Fungal infection

6. Abnormal drug response due to genetic abnormality means:

A A. Supersensitivity B B. Addiction C C. Idiosyncrasy D D. Tachyphylaxis

7. Drug with the following therapeutic index is highly toxic:

A A) 100 B B) Three C B) Three D D) 500

8. The analgesic of choice for toothache in patients suffering from peptic ulcer is:

A A) Methylsalicylate B B) Paracetamol C C) Acetylsalicylic acid D C) Acetylsalicylic acid

9- The following drug has no antiinflammatory action:

A A) Acetylsalicylic acid B B) Sodium salicylates C C) Diclofenac D D) Paracetamol

10. Pharmacological actions of corticosteroids NOT include:

A A) Anti-inflammatory B B) Antiallergic C C) Immunosuppressive effect D D) hypoglycemic effect

11. Study of the causes of diseases is called:

A A) Prognosis B B) B Etiology C C) Pathogenesis D C) Pathogenesis

12. The mechanism through which the cause of a disease operates to produce the pathological and clinical manifestations is called:

A Etiology B Pathology C Pathogenesis D Complications

13. Which of the following types of necrosis is most likely to be seen in the brain?

A A) Caseous necrosis B B) Coagulative necrosis C C) Enzymatic fat necrosis D D) Liquefactive necrosis

14. Which of the followings best describes karyolysis?

A A) Condensed chromatin B B) Dissolution of chromatin C C) Fragmentation of chromatin D D) Shrinkage of chromatin

15. The following is an irreversible Apoptosis

A A) Apoptosis B B) Cloudy swelling C C) Fatty change D D) Hydropic change

16. Programmed cell death is called:

A A) Degeneration B B) Necrosis C C) Aplasia D D) Apoptosis

17. Change of one type of epithelium to another type is called:

A A) Aplasia B B) Atrophy C c) Metaplasia D d) Hyperplasia

18. Increase in size of tissue or organ due to an increase in the number of its individual cells is called:

A A) Hyperplasia B B) Hypertrophy C C) Metaplasia D D) Dysplasia

19. Phagocytosis is enhanced by:

A A) Bradykinin B B) Histamine C C) Lysozyme D D) Opsonin

20. The primary cells in chronic inflammation are:

A A) Macrophages B B) Microphages X C C) Neutrophils X D D) Plasma cells

21. All of the followings are infective granulomas EXCEPT:

A A) Tuberculosis B A) Tuberculosis C D) Leprosy D C) Bilharziasis

..22. An example of diffuse suppurative inflammation is:

A Abscess B Rhinitis C Rhinitis D Pericarditis

23. The following chemical mediator is strongly related to chemotaxis:

A Bradykinin B C5a C Histamine D Serotonin

24. Suppurative inflammation related to hair follicle is called:

A Cellulitis B Furuncle C Carbuncle D Granuloma

25. The most predominant cells in acute inflammation are:

A Neutrophils B Macrophages C Eosinophils D Lymphocytes

26. Persistent loss of continuity of the surface epithelium of the skin or mucous membranes is called:

A Keloid B Fistula C Ulcer D Sinus

27. Putrefaction in gangrene is caused by:

A A. Saprophytic bacteria B B) Pyogenic bacteria C C) Venous obstruction D D) Ischemia

28. Decreased blood supply to a tissue is called:

A A) Hyperemia B B) Ischemia C C) Congestion D D) Infarction

29. The followings are degenerative diseases EXCEPT:

A E) Alzheimer's syndrome B F) Anemia C G) Hypertension D H) Parkinson's disease Adres

30. Manifestations of neoplastic diseases include the following:

A I) Weight loss B J) Fatigue C K) Fever D L) All of the above

31. The followings are systemic manifestations of inflammation EXCEPT:

A a. Tachycardia B b. Tachypnea C c. Diarrhea D d. Fever

32. Familial colon cancer is related to:

A A) Retinoblastoma B b) Familial polyposis coli C c) Neurofibromatosis D d) Multiple endocrine neoplasia

33. Regarding to the onset of action; the most rapid route is:

A A) Subcutaneous B B) Intravenous C C) Oral D D) Sublingual

34. First pass effect occurs on drugs taken:

A Intravenous B Oral C Sublingual D None of above

35. The following is not a passive process of passage of drugs through cell membranes:

A A) Simple diffusion B B) Endocytosis C C) Filtration D D) Filtration

36. Active transport process of drug passage through cell membranes is 36. Active transport process of drug passage through cell membranes is

A a) Occurs along concentration gradient B B) Occurs along concentration gradient C c) Saturable D D) Competitive inhibition

37. Drug absorption from s.c tissues is decreased in case of:

A A) Warming of site of injection B B) Shock C C) Massaging site of injection D D) None of the above

38. The ultrashort action of thiopental is due to:

A A) Rapid excretion B b) Rapid redistribution C c) Rapid metabolism D d) Rapid redistribution

39. Biological half-life ( t 1/2 ) of drugs determines:

A Duration of action B Both of the above C Frequency of dosage D None of the above

40. As regarding to protein binding the following is NOT true:

A Decreases rate of distribution B Prolongs the half life C Increases rate of metabolism D Delays drug clearance

1. All of the followings are correct for moist gangrene EXCEPT:

A A) Poor line of demarcation B B) Severe toxemia C C) Occurs in intestine D D) Self separation may occur

2. An abscess is best defined as:

A A) A local defect in the surface of a tissue B C) An epithelial-lined sac filled with viscous fluid C C) An epithelial-lined sac filled with viscous fluid D D) localized collection of pus

3. Any substance that is capable of causing cancer is called:

A A) Mutagen B B) Carcinogen C C) Tumor gene D D) Oncogen

4. Secondary implant discontinuous with the primary tumor is called:

A A) A Metastasis B B) Invasion C C) Infiltration D D) Metaplasia

5. Which of the followings is the source of epithelioid cells in granuloma?

A A) Macrophages B B) Lymphocytes C C) Neutrophils D D) Plasma cells

6. Which of the followings is one of the criteria of anaplasia in malignancy?

A A) Pyknosis B B) Pleomorphism C C) Hyalinosis D D) Apoptosis

7. Benign tumor of glandular epithelium is called:

A A) Adenoma B B) Papilloma C C) Glandoma D D) Adenocarcinoma

8. The following is NOT a type of necrosis:

A A) Coagulative B B) Fat C C) Liquifactive D A) D Degenerativement cons

9. The followings are labile cells that proliferate continuously throughout life:

A A) Liver cells B B) Pancreatic cells C c) Cells of epidermis D d) Cells of renal tubules

10. Weak Alkaline drug in alkaline media is more:

A (A) Unionized B (B) Ionized C C) Not lipid soluble D D) All of above

11. The following are adverse effects of drugs EXCEPT:

A A) Idiosyncrasy B B) Allergy C C) Tolerance D D) Side effects

12. Absorption is mostly high for:

A A) Water soluble drugs B B) BLipid soluble drugs C C) Neutral drugs D D) None of above

13, Bioavailability of drug is increased with increasing:

A A) Lipid solubility. B B) Drug ionization C C) Both a and b D D) None of above

14. Children with viral infections should avoid:

A A) Diclofenac B b) Acetylsalicylic acid C c) Paracetamol D d) Indomethacin

15. The drug can pass easily the blood brain barrier if it is:

A A) Water soluble B B) Ionized C c) Highly lipid soluble D d) None of the above

16. Types of receptor ligands (drugs) include the following:

A Agonist B Antagonist C Agonist-antagonist D All of the above

17. Salicylates act through inhibition of synthesis of:

A Serotonin B Leukotrienes C Prostaglandins D Histamine

18. The first discovered antibiotic is:

A A) Penicillin B B) Cephalosporins C C) Quinolones D D) Tetracyclines

19. Histamine is released in the body from:

A A) Macrophage cells B B) Mast cells C C) Lymphocytes D D) Hepatocytes

20. Manifestations of neoplastic diseases include the following:

A A) Weight loss B B) Fatigue C C) Fever D D) All of the above

1. All of the followings are correct for thrombus EXCEPT;

A A) Circulating in the blood B B) Common in atherosclerosis C C) May be disappear if it is small D D) May be infected

2. All of the followings are correct for cardiac edema EXCEPT:

A A) Generalized edema B B) Increased hydrostatic pressure C C) Occurs in heart failure D D) One of the circulatory disturbances E E) Starts in upper limb

3. Which of the following types of necrosis is most likely to be seen in the brain

A A) Caseous necrosis B B) Coagulative necrosis C C) Enzymatic fat necrosis D D) Gangrenous necrosis E E) Liquefactive necrosis

4. Change of one type of epithelium to another type is called:

A A) Aplasia B B) Atrophy C C) Hyperplasia D D) Hypertrophy E E) Metaplasia

5. Persistent loss of continuity of the surface epithelium of the skin or mucous membrane is called:

A Keloid B Fistula C Sinus D Ulcer

6. The following is a benign tumor:

A Granuloma B Hamartoma C Hematoma D Lymphoma E Papilloma

7. Nuclear pleomorphism is a defining characteristic of:

A Anaplasia B Hyperplasia C Hypertrophy D Metaplasia

8. The following is a feature of granulation tissue:

A Densely collagenized B Insensitive C Poorly cellular D Poorly vascular

9. The following is NOT considered a primary site for tuberculosis:

A Intestine B Kidneys C Lungs D Skin

10. Russel bodies are an example of:

A A) Extracellular accumulation of abnormal constituents B B) Extracellular accumulation of normal constituents C C) Intracellular accumulation of abnormal constituents D D) Intracellular accumulation of normal constituents

12. Oncogene is:

A A mutant gene B A regulatory gene C Aberrant chromatid D Abnormal chromatin

13. About the treatment of the degenerative diseases all of the followings are correct EXCEPT:

A A) Some are curable like some tumors B B) Some are incurable like neurological diseases C C) Some are controlled like hypertension and Myocardial infarction D D) All of the above

14. The followings are cardinal signs of inflammation EXCEPT:

A Hotness B Loss of function C Painful D Painless

15. Diagnosis of genetic diseases includes the followings EXCEPT:

A Amniotic fluid sample B Blood samples C Hair samples D Skin samples

16. Familial colon cancer is related to:

A Breast cancer B Familial polyposis coli C Multiple endocrine neoplasia D Neurofibromatosis

17. The followings are degenerative diseases EXCEPT:

A Alzheimer's syndrome B Dissolution of chromatin C Fragmentation of chromati D Hyperchromatism

20. Which of the following routes of spread occurs early in sarcomas?

A Lymphatic B Hematogenous C Natural passages D Body cavities

21. Phagocytosis is enhanced by:

A Bradykinin B Histamine C Lysozyme D Opsonin

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